It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir, and tenofovir alafenamide. Both Prezcobix and Evotaz were approved by the FDA in January 2015.Ĭobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. Īdditionally, in existence are a fixed-dose combination of cobicistat and protease inhibitor darunavir ( darunavir/cobicistat marketed as Prezcobix by Janssen Therapeutics), and a fixed-dose combination of cobicistat and protease inhibitor atazanavir ( atazanavir/cobicistat marketed as Evotaz by Bristol-Myers Squibb). The third, cobicistat, darunavir, emtricitabine, and tenofovir alafenamide, is marketed as Symtuza and was FDA approved Jand is owned by Janssen Pharmaceuticals. Both Stribild and Genvoya are owned by Gilead Sciences. The second, elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, is marketed as Genvoya and was approved by the FDA in November 2015 for use in the United States. The first, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil, is marketed as Stribild and was approved by the FDA in August 2012 for use in the United States. Ĭobicistat is a component of three four-drug, fixed-dose combination HIV treatments. In contrast with ritonavir, the only other booster approved for use as a part of HAART, cobicistat has no anti-HIV activity of its own. By combining cobicistat with elvitegravir, higher concentrations of the latter are achieved in the body with lower dosing, theoretically enhancing elvitegravir's viral suppression while diminishing its adverse side-effects. Like ritonavir (Norvir), cobicistat is of interest for its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor. Its major mechanism of action is through the inhibition of human CYP3A proteins. Cobicistat, sold under the brand name Tybost, is a medication for use in the treatment of human immunodeficiency virus infection ( HIV/AIDS).
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